Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives (2024)

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Volume 71 Issue 9 1 September 2013
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Margarita González-Vallinas

IMDEA-Food Institute, Madrid, Spain

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Marta González-Castejón

IMDEA-Food Institute, Madrid, Spain

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Arantxa Rodríguez-Casado

IMDEA-Food Institute, Madrid, Spain

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Ana Ramírez de Molina

IMDEA-Food Institute, Madrid, Spain

Correspondence: A Ramírez de Molina, C/Faraday 7, CLAID building D1.06, Cantoblanco, 28049 Madrid, Spain. E-mail: ana.ramirez@imdea.org. Phone: +34-912796957. Fax: +34-911880756.

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Nutrition Reviews, Volume 71, Issue 9, 1 September 2013, Pages 585–599, https://doi.org/10.1111/nure.12051

Published:

01 September 2013

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    Margarita González-Vallinas, Marta González-Castejón, Arantxa Rodríguez-Casado, Ana Ramírez de Molina, Dietary phytochemicals in cancer prevention and therapy: a complementary approach with promising perspectives, Nutrition Reviews, Volume 71, Issue 9, 1 September 2013, Pages 585–599, https://doi.org/10.1111/nure.12051

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Abstract

The population is aging. Over the coming years, the incidence of age-related chronic diseases such as cancer is expected to continue to increase. Phytochemicals, which are non-nutritive chemicals found in plants and food, have emerged as modulators of key cellular signaling pathways exerting proven anticancer effects. The challenge now is to develop personalized supplements comprised of specific phytochemicals for each clinical situation. This will be possible once a better understanding is gained of the molecular basis explaining the impact of phytochemicals on human health. The aim of the present literature review is to summarize current knowledge of the dietary phytochemicals with proven antitumor activity, with a special emphasis placed on their molecular targets. Also discussed are the limits of existing research strategies and the future directions of this field.

cancer, dietary phytochemicals, nutrigenomics, nutritional supplements, polyphenols, prevention, therapy

© 2013 International Life Sciences Institute

Topic:

  • cancer
  • diet
  • plants
  • phytochemicals
  • cancer prevention
  • molecular target

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